Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | EDNRA | P25101 | 2/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30337937 | 1.00 | CNR1 (0.40) | CNR1CNR2ADAM17MEN1NPC1 | |
| SCHEMBL23886693 | 1.00 | CNR1 (0.40) | CNR1CNR2ADAM17MEN1NPC1 | |
| SCHEMBL30337929 | 0.87 | CNR1 (0.40) | CNR1CNR2MEN1NPC1RAB9A | |
| SCHEMBL30176374 | 0.86 | S1PR5 (0.42) | CNR1CNR2MEN1NPC1RAB9A | |
| SCHEMBL23886923 | 0.86 | S1PR5 (0.42) | CNR1CNR2MEN1NPC1RAB9A | |
| SCHEMBL23886757 | 0.82 | EDNRB (0.40) | CNR1CNR2ADAM17MEN1NPC1 | |
| SCHEMBL30176365 | 0.82 | EDNRB (0.40) | CNR1CNR2ADAM17MEN1NPC1 | |
| SCHEMBL30337850 | 0.82 | EDNRB (0.40) | CNR1CNR2ADAM17MEN1NPC1 | |
| SCHEMBL23886848 | 0.78 | PLA2G4A (0.46) | MEN1NPC1RAB9AKMT2AEDNRB | |
| SCHEMBL30176331 | 0.78 | PLA2G4A (0.46) | MEN1NPC1RAB9AKMT2AEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |