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Sugi Predict / Targets / PLA2G4A

PLA2G4A

Cytosolic phospholipase A2 · P47712 · PLA2G4A on Sugi Atlas →

91,302 patent compounds predicted against PLA2G4A, 25,888 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL82270 SCHEMBL82270 1.00 20/20
SCHEMBL82285 SCHEMBL82285 1.00 20/20
SCHEMBL82666 SCHEMBL82666 1.00 20/20
SCHEMBL82698 SCHEMBL82698 1.00 20/20
SCHEMBL82699 SCHEMBL82699 1.00 20/20
SCHEMBL82817 SCHEMBL82817 1.00 20/20
SCHEMBL82965 SCHEMBL82965 1.00 20/20
SCHEMBL83003 SCHEMBL83003 1.00 20/20
SCHEMBL83500 SCHEMBL83500 1.00 20/20
SCHEMBL84145 SCHEMBL84145 1.00 20/20
SCHEMBL88873 SCHEMBL88873 1.00 20/20
SCHEMBL460992 SCHEMBL460992 1.00 20/20
SCHEMBL83550 SCHEMBL83550 0.91 20/20
SCHEMBL82663 SCHEMBL82663 0.89 20/20
SCHEMBL82250 SCHEMBL82250 0.89 20/20
SCHEMBL90612 SCHEMBL90612 0.89 20/20
SCHEMBL82559 SCHEMBL82559 0.88 20/20
SCHEMBL81219 SCHEMBL81219 0.87 20/20
SCHEMBL83635 SCHEMBL83635 0.86 20/20
SCHEMBL84216 SCHEMBL84216 0.85 20/20

Clinical trials — most relevant to PLA2G4A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study PHASE4COMPLETED
Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL) PHASE4COMPLETED
Comparative Assessment of Preoperative Versus Postoperative Submucosal Dexamethasone on Postoperative Complications Following Surgical Extraction of Mandibular Third Molar: Randomized Controlled Trial PHASE4NOT_YET_RECRUITING
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis PHASE3COMPLETED
European Celecoxib Trial in Primary Breast Cancer PHASE3COMPLETED
Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM PHASE3COMPLETED
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes PHASE3UNKNOWN
Montelukast in Parkinson Disease PHASE2/PHASE3RECRUITING
Montelukast for Early Life Wheezing PHASE2/PHASE3COMPLETED
Lovaza's Effect on the Activation of Platelets PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies nanUNKNOWN
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke nanCOMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis. nanCOMPLETED
Role of PLA2G1B During HIV Infection nanUNKNOWN
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes nanCOMPLETED
Mucomyst for Hepatitis C nanSUSPENDED
Role of Anti-mouse PLA2R1 ELISA in Membranous Nephropathy nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Positron Emission Tomography (PET) to Study Brain Signaling nanCOMPLETED
PET Imaging of DHA Metabolism nanCOMPLETED
LDL-Apheresis for FSGS CardioRenal Outcomes nanCOMPLETED
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions nanCOMPLETED
Relation Between Prostaglandin E2 Metabolite Levels and the Development of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Neonates nanRECRUITING
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses nanCOMPLETED
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients nanCOMPLETED
Autotaxin (ATX) as a Marker for Breast Cancer nanUNKNOWN
Molecular Markers of Human Sperm Function nanWITHDRAWN
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations nanCOMPLETED
Lp-PLA2 and Coronary Atherosclerosis in Humans nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PLA2G4A binder may also engage these)

ProteinNameSimilarity
Q5R8A5 — 1.000 Q5R8A5 →
Q9TT38 — 1.000 Q9TT38 →
P49147 — 1.000 P49147 →
A4IFJ5 — 1.000 A4IFJ5 →
P47713 — 0.999 P47713 →
P50392 — 0.996 P50392 →
P50393 — 0.996 P50393 →
O77793 — 0.996 O77793 →
B1WAZ6 — 0.995 B1WAZ6 →
Q7T0T9 — 0.994 Q7T0T9 →
PLA2G4C Cytosolic phospholipase A2 gamma 0.965 landscape →
Q5ZJV4 — 0.965 Q5ZJV4 →
Q8N1G2 — 0.964 Q8N1G2 →
B1H268 — 0.964 B1H268 →
Q8C5P5 — 0.963 Q8C5P5 →
Q5R981 — 0.963 Q5R981 →
E9Q4Z2 — 0.963 E9Q4Z2 →
Q9NXN4 — 0.962 Q9NXN4 →
Q9C5E5 — 0.962 Q9C5E5 →
Q9BXW6 — 0.962 Q9BXW6 →
Q60HG1 — 0.961 Q60HG1 →
Q641K1 — 0.961 Q641K1 →
Q8K4M9 — 0.961 Q8K4M9 →
Q2KIX2 — 0.961 Q2KIX2 →
Q8IYB8 — 0.961 Q8IYB8 →
Q7XQT2 — 0.960 Q7XQT2 →
P98192 — 0.960 P98192 →
Q28CF8 — 0.960 Q28CF8 →
Q9DBC3 — 0.960 Q9DBC3 →
Q6DDX8 — 0.960 Q6DDX8 →