Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.35 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23886672 | 1.00 | MRGPRX4 (0.35) | MRGPRX4AS3MTPTGER1LMNAMAPT | |
| SCHEMBL23898683 | 0.83 | AS3MT (0.38) | AS3MTPTGER1LMNAMAPTTSHR | |
| SCHEMBL30176398 | 0.83 | AS3MT (0.42) | AS3MTPTGER1LMNAMAPTTSHR | |
| SCHEMBL23886810 | 0.83 | AS3MT (0.42) | AS3MTPTGER1LMNAMAPTTSHR | |
| SCHEMBL23898684 | 0.71 | AS3MT (0.40) | AS3MTLMNAMAPTTSHRHTT | |
| SCHEMBL23898401 | 0.69 | KDM4E (0.35) | LMNAMAPTTSHRHTT | |
| SCHEMBL26652990 | 0.68 | KDM4E (0.36) | LMNAMAPTTSHRHTT | |
| SCHEMBL30335469 | 0.67 | PTGER1 (0.37) | PTGER1MAPTKDM1A | |
| SCHEMBL23883823 | 0.67 | PTGER1 (0.37) | PTGER1MAPTKDM1A | |
| SCHEMBL23886911 | 0.67 | LMNA (0.36) | LMNAMAPTTSHRKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916749-A | Substituted 5-hydroxyindole compounds as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |