Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 4/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887132 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2FYNMAPTKDM4EALDH1A1 | |
| SCHEMBL30708510 | 0.85 | FYN (0.36) | SMN1; SMN2FYNMAPTKDM4EALDH1A1 | |
| SCHEMBL7595839 | 0.82 | FYN (0.35) | FYNMMP2MMP3MMP9MMP14 | |
| SCHEMBL6322208 | 0.81 | NQO1 (0.50) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL614591 | 0.79 | PIK3CD (0.40) | SMN1; SMN2FYNMAPTKDM4EALDH1A1 | |
| SCHEMBL1527596 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2803033 | 0.78 | CA12 (0.43) | SMN1; SMN2MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL13285991 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2FYNMAPTFFAR1MAOB | |
| SCHEMBL2176515 | 0.78 | FYN (0.45) | FYNMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2171833 | 0.78 | EGFR (0.43) | SMN1; SMN2FYNMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916749-A | Substituted 5-hydroxyindole compounds as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |