Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.79 |
| ▸ | CDK2 | P24941 | 4/20 | 0.75 |
| ▸ | CDK1 | P06493 | 6/20 | 0.62 |
| ▸ | CCND1 | P24385 | 3/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.62 |
| ▸ | FECH | P22830 | 1/20 | 0.62 |
| ▸ | CCND3 | P30281 | 1/20 | 0.62 |
| ▸ | CDK9 | P50750 | 1/20 | 0.62 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.62 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.62 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.62 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.62 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.62 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.62 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302054 | 1.00 | CDK4 (0.79) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL29507417 | 0.91 | CDK4 (0.65) | CDK4CDK2CDK1CCND1GAK | |
| Dimethylamine SCHEMBL27085314 | 0.90 | CDK4 (0.63) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL1991249 | 0.89 | CDK4 (0.78) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL30176576 | 0.88 | CDK4 (0.79) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL302194 | 0.88 | CDK4 (0.79) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL305292 | 0.88 | CDK4 (1.00) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL31060834 | 0.88 | CDK4 (1.00) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL1989299 | 0.86 | CDK2 (1.00) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL2298391 | 0.85 | CDK4 (1.00) | CDK4CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126244-A1 | COMBINATION OF ANTI-HER2 ANTIBODY AND CDK INHIBITIOR FOR TUMOR TREATMENT | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (CN) | 2023-02-08 | — | — | EP | claimed |
| EP-4126244-A1 | COMBINATION OF ANTI-HER2 ANTIBODY AND CDK INHIBITIOR FOR TUMOR TREATMENT | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (CN) | 2023-02-08 | — | — | EP | disclosed |