Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.79 |
| ▸ | CDK2 | P24941 | 6/20 | 0.74 |
| ▸ | CDK1 | P06493 | 8/20 | 0.64 |
| ▸ | CCND1 | P24385 | 3/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.61 |
| ▸ | FECH | P22830 | 1/20 | 0.61 |
| ▸ | CCND3 | P30281 | 1/20 | 0.61 |
| ▸ | CDK9 | P50750 | 1/20 | 0.61 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.61 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.61 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.61 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.61 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.61 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.61 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302194 | 1.00 | CDK4 (0.79) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL29507624 | 0.90 | CDK4 (0.64) | CDK4CDK2CDK1CDK6 | |
| Dimethylamine SCHEMBL28726089 | 0.90 | CDK4 (0.64) | CDK4CDK2CDK1CCND1CCND3 | |
| SCHEMBL303640 | 0.89 | CDK4 (0.79) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL30176545 | 0.89 | CDK4 (0.79) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL30176552 | 0.88 | CDK4 (0.79) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL30176619 | 0.88 | CDK4 (1.00) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL302054 | 0.88 | CDK4 (0.79) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL303197 | 0.88 | CDK4 (1.00) | CDK4CDK2CDK1CCND1GAK | |
| SCHEMBL1991249 | 0.88 | CDK4 (0.78) | CDK4CDK2CDK1CCND1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126244-A1 | COMBINATION OF ANTI-HER2 ANTIBODY AND CDK INHIBITIOR FOR TUMOR TREATMENT | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (CN) | 2023-02-08 | — | — | EP | claimed |
| US-20230118053-A1 | COMBINATION OF ANTI-HER2 ANTIBODY AND CDK INHIBITIOR FOR TUMOR TREATMENT | JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| EP-4126244-A1 | COMBINATION OF ANTI-HER2 ANTIBODY AND CDK INHIBITIOR FOR TUMOR TREATMENT | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (CN) | 2023-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230118053-A1 | COMBINATION OF ANTI-HER2 ANTIBODY AND CDK INHIBITIOR FOR TUMOR TREATMENT | CDK6, CDK4, CDK2 | CDK4 2/4885CDK2 3/4885CDK1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.