Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25274312 | 1.00 | MAPT (0.44) | MAPTMAPK1CYP2C19ALDH1A1MEN1 | |
| SCHEMBL25719680 | 0.90 | MAPT (0.45) | MAPTMAPK1CYP2C19ALDH1A1MEN1 | |
| SCHEMBL23884805 | 0.86 | MAPT (0.40) | MAPTMAPK1CYP2C19ALDH1A1MEN1 | |
| SCHEMBL23884691 | 0.86 | MEN1 (0.39) | ALDH1A1MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL23884683 | 0.84 | HCRTR2 (0.47) | MAPTMAPK1MEN1KMT2AHCRTR2 | |
| SCHEMBL30177220 | 0.82 | MAPT (0.44) | MAPTMAPK1MEN1KMT2AHCRTR2 | |
| SCHEMBL23884694 | 0.82 | MAPT (0.44) | MAPTMAPK1MEN1KMT2AHCRTR2 | |
| SCHEMBL30177281 | 0.82 | MAPT (0.36) | MAPTMAPK1CYP2C19ALDH1A1MEN1 | |
| SCHEMBL23884695 | 0.82 | MAPT (0.36) | MAPTMAPK1CYP2C19ALDH1A1MEN1 | |
| SCHEMBL25590617 | 0.80 | HCRTR2 (0.36) | CYP2C19HCRTR2HSD11B1HCRTR1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126832-A1 | MODULATORS OF HEMOGLOBIN | Global Blood Therapeutics, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |