Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30178663 | 1.00 | TMEM97 (0.36) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL25602819 | 1.00 | TMEM97 (0.36) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL25624409 | 0.94 | SMN1; SMN2 (0.38) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL25224353 | 0.89 | GRIN2B (0.37) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL30178778 | 0.89 | GRIN2B (0.37) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL24838315 | 0.89 | SMARCA2 (0.42) | HRH3 | |
| SCHEMBL24837913 | 0.87 | SMARCA2 (0.43) | HRH3NPC1RAB9A | |
| SCHEMBL24838328 | 0.87 | SMARCA2 (0.41) | HRH3 | |
| SCHEMBL30179049 | 0.85 | SMARCA2 (0.40) | — | |
| SCHEMBL30178943 | 0.85 | SMARCA2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |