Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 10/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25224353 | 1.00 | GRIN2B (0.37) | GRIN2BCYP2D6CYP2C9CYP3A4CHRM2 | |
| SCHEMBL25624409 | 0.95 | SMN1; SMN2 (0.38) | GRIN2BCYP2D6CYP2C9CHRM2CHRM1 | |
| SCHEMBL24837893 | 0.90 | SMARCA2 (0.41) | — | |
| SCHEMBL30178663 | 0.89 | TMEM97 (0.36) | GRIN2BCYP2D6CYP2C9CHRM2CHRM1 | |
| SCHEMBL30179045 | 0.89 | TMEM97 (0.36) | GRIN2BCYP2D6CYP2C9CHRM2CHRM1 | |
| SCHEMBL25602819 | 0.89 | TMEM97 (0.36) | GRIN2BCYP2D6CYP2C9CHRM2CHRM1 | |
| SCHEMBL30178717 | 0.87 | SMARCA2 (0.43) | — | |
| SCHEMBL24838422 | 0.87 | SMARCA2 (0.43) | — | |
| SCHEMBL30179168 | 0.85 | SMARCA2 (0.42) | CHRM2CHRM1CHRM4 | |
| SCHEMBL30178526 | 0.85 | SMARCA2 (0.42) | CHRM2CHRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |