Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30178526 | 1.00 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1TERTCNR1 | |
| SCHEMBL24838428 | 0.98 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1TERTCNR1 | |
| SCHEMBL30178473 | 0.98 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1TERTCNR1 | |
| SCHEMBL24838427 | 0.98 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1TERTCNR1 | |
| SCHEMBL24837893 | 0.96 | SMARCA2 (0.41) | SMARCA2SMARCA4PBRM1PARP1KDM4E | |
| SCHEMBL24838422 | 0.93 | SMARCA2 (0.43) | SMARCA2SMARCA4PBRM1TERTKIT | |
| SCHEMBL30178717 | 0.93 | SMARCA2 (0.43) | SMARCA2SMARCA4PBRM1TERTKIT | |
| SCHEMBL24838421 | 0.91 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1KIT | |
| SCHEMBL24837880 | 0.91 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1KIT | |
| SCHEMBL24838737 | 0.91 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |