Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.83 |
| ▸ | ARG2 | P78540 | 4/20 | 0.52 |
| ▸ | ARG1 | P05089 | 3/20 | 0.52 |
| ▸ | NOS2 | P35228 | 6/20 | 0.50 |
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | NOS3 | P29474 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL6538526 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL15753994 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL19742881 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1433568 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL5581427 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL302610 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28318609 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1696587 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL7861429 | 1.00 | GSR (0.83) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL9448118 | 0.98 | GSR (0.80) | GSRARG2ARG1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004380-A1 | DIAGNOSIS, PROPHYLAXIS AND THERAPY OF ALZHEIMER'S DISEASE AND OTHER NEURODEMENTING DISORDERS | BALAKRISHNAN KARTHIKEYAN (DE) | 2012-01-12 | — | — | WO | claimed |
| EP-2404612-A1 | Diagnosis, prophylaxis and therapy of Alzheimer's disease and other neurodementing disorders | Balakrishnan, Karthikeyan (DE) | 2012-01-11 | — | — | EP | claimed |
| EP-1944314-A1 | Diagnosis of Alzheimer's disease and other neurodementing disorders | Philipps-Universität Marburg (DE) | 2008-07-16 | — | — | EP | claimed |
| EP-2104682-B1 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S AND OTHER NEURODEMENTING DISEASES | BACHER MICHAEL (DE) | 2016-09-21 | — | — | EP | disclosed |
| US-8491903-B2 | Method of treatment of neurodementing diseases using isolated, monoclonal, human, anti-B-amyloid antibody | PHILIPPS-UNIVERSITAET MARBURG (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20120040382-A1 | METHOD OF DETECTING PROGRESSION OF A NEURODEMENTING DISEASE | PHILIPPS-UNIVERSITAET MARBURG (DE) | 2012-02-16 | — | — | US | disclosed |
| US-20120039897-A1 | METHOD OF TREATMENT OF NEURODEMENTING DISEASES USING ISOLATED, MONOCLONAL, HUMAN, ANTI-B-AMYLOID ANTIBODY | Philipps-Universitaet Marbrug (DE) | 2012-02-16 | — | — | US | disclosed |
| WO-2012004380-A1 | DIAGNOSIS, PROPHYLAXIS AND THERAPY OF ALZHEIMER'S DISEASE AND OTHER NEURODEMENTING DISORDERS | BALAKRISHNAN KARTHIKEYAN (DE) | 2012-01-12 | — | — | WO | disclosed |
| EP-2404612-A1 | Diagnosis, prophylaxis and therapy of Alzheimer's disease and other neurodementing disorders | Balakrishnan, Karthikeyan (DE) | 2012-01-11 | — | — | EP | disclosed |
| US-7939075-B2 | Human monoclonal anti-amyloid-beta antibodies | PHILIPPS-UNIVERSITAET MARBURG (DE) | 2011-05-10 | — | — | US | disclosed |
| EP-2104682-A2 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S AND OTHER NEURODEMENTING DISEASES | Philipps-Universität Marburg (DE) | 2009-09-30 | — | — | EP | disclosed |
| US-20090028869-A1 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S AND OTHER NEURODEMENTING DISEASES | PHILIPPS-UNIVERSITAET MARBURG | 2009-01-29 | — | — | US | disclosed |
| WO-2008084402-A2 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S AND OTHER NEURODEMENTING DISEASES | PHILIPPS-UNIVERSITAET MARBURG (US) | 2008-07-17 | — | — | WO | disclosed |
| EP-1944314-A1 | Diagnosis of Alzheimer's disease and other neurodementing disorders | Philipps-Universität Marburg (DE) | 2008-07-16 | — | — | EP | disclosed |
| EP-1944315-A1 | Prophylaxis and therapy of alzheimer's disease and other neurodementing diseases | Philipps-Universität Marburg (DE) | 2008-07-16 | — | — | EP | disclosed |