SCHEMBL30180296

SCHEMBL30180296

Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccc(N6CCC6)cc45)cn3)cc2)ccn1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.48
RAB9A P51151 3/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
NPC1 O15118 2/20 0.48
MAPKAPK2 P49137 12/20 0.44
USP2 O75604 2/20 0.43
KMT2A Q03164 2/20 0.43
ALDH1A1 P00352 2/20 0.43
KDM4E B2RXH2 1/20 0.42
POLB P06746 1/20 0.42
THRB P10828 1/20 0.42
MAPK1 P28482 1/20 0.42
MCL1 Q07820 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
DNMT1 P26358 2/20 0.41
DNMT3A Q9Y6K1 2/20 0.41
ADRA2A P08913 1/20 0.41
ADRA2B P18089 1/20 0.41
ADRA2C P18825 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23999596 1.00 MAPT (0.48) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL23999785 0.93 MAPT (0.54) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL30180392 0.93 MAPT (0.54) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL30180473 0.90 MAPT (0.53) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL23999636 0.90 MAPT (0.53) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL24005994 0.87 DNMT1 (0.59) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL30180365 0.86 MAPT (0.45) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL23999440 0.86 MAPT (0.45) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL23999637 0.84 MAPT (0.45) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2
SCHEMBL30180369 0.84 MAPT (0.45) MAPTRAB9ASMN1; SMN2NPC1MAPKAPK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4426279-A1 AKT3 MODULATORS Georgiamune Inc. (US) 2024-09-11 EP disclosed
CN-118524833-A AKT3 modulators 乔治穆内公司 2024-08-20 CN disclosed
WO-2023081854-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
CN-115867562-A AKT3 modulators 乔治穆内有限责任公司 2023-03-28 CN disclosed
EP-4146667-A1 AKT3 MODULATORS Georgiamune LLC (US) 2023-03-15 EP disclosed