Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.82 |
| ▸ | USP2 | O75604 | 2/20 | 0.82 |
| ▸ | POLB | P06746 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 5/20 | 0.55 |
| ▸ | DNMT3A | Q9Y6K1 | 4/20 | 0.55 |
| ▸ | DNMT3L | Q9UJW3 | 2/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19151335 | 1.00 | MAPT (0.82) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL25825372 | 0.93 | KMT2A (0.70) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL19124864 | 0.91 | MAPT (1.00) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL19151333 | 0.86 | MAPT (0.60) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL19151411 | 0.85 | KMT2A (0.59) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL30180798 | 0.85 | KMT2A (0.59) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL22793632 | 0.85 | MAPT (0.59) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL30180507 | 0.84 | KMT2A (0.80) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL19151510 | 0.84 | KMT2A (0.80) | MAPTKMT2AUSP2POLBMAPK1 | |
| SCHEMBL30180389 | 0.83 | KMT2A (0.57) | MAPTKMT2AUSP2POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426279-A1 | AKT3 MODULATORS | Georgiamune Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| CN-118524833-A | AKT3 modulators | 乔治穆内公司 | 2024-08-20 | — | — | CN | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-115867562-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4146667-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |