Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.55 |
| ▸ | EGFR | P00533 | 11/20 | 0.55 |
| ▸ | ABL1 | P00519 | 8/20 | 0.55 |
| ▸ | ABL2 | P42684 | 8/20 | 0.55 |
| ▸ | CDK1 | P06493 | 7/20 | 0.55 |
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.53 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | CSK | P41240 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966673 | 1.00 | SRC (0.55) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL30180934 | 0.88 | RIPK2 (0.56) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL23966926 | 0.88 | RIPK2 (0.56) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL20351783 | 0.77 | RIPK2 (0.61) | SRCRIPK2 | |
| SCHEMBL30813603 | 0.75 | SRC (0.48) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL27217632 | 0.75 | SRC (0.48) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL25793524 | 0.74 | NEK7 (0.83) | NEK7 | |
| SCHEMBL7842356 | 0.74 | SRC (0.82) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL24072588 | 0.74 | PI4KB (0.57) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL29484520 | 0.74 | PI4KB (0.57) | SRCEGFRABL1ABL2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115843272-A | Inhibitors of NEK7 kinase | 哈利亚治疗公司 | 2023-03-24 | — | — | CN | disclosed |
| EP-4146348-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |