Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047768 | 0.84 | CYP11B1 (0.60) | NPC1RAB9AFGFR1SMN1; SMN2TSHR | |
| SCHEMBL22533982 | 0.82 | FGFR1 (0.49) | NPC1RAB9AFGFR1MAPTSMN1; SMN2 | |
| SCHEMBL13508672 | 0.80 | KCNH2 (0.62) | NPC1RAB9AFGFR1BRD4MAPT | |
| SCHEMBL7215799 | 0.79 | CYP11B1 (0.67) | RAB9ABRD4SMN1; SMN2TSHRGAA | |
| SCHEMBL19911343 | 0.78 | FGFR1 (0.54) | NPC1RAB9AFGFR1BRD4MAPT | |
| SCHEMBL28481231 | 0.77 | HTR2C (0.51) | TP53ALOX5APNR1I2 | |
| SCHEMBL6758619 | 0.76 | NPC1 (0.65) | NPC1RAB9AFGFR1MAPTSMN1; SMN2 | |
| SCHEMBL19848376 | 0.75 | FGFR1 (0.54) | NPC1RAB9AFGFR1MAPTSMN1; SMN2 | |
| SCHEMBL27441644 | 0.74 | QPCT (0.54) | NPC1RAB9AFGFR1BRD4MAPT | |
| SCHEMBL19848229 | 0.74 | FGFR1 (0.50) | NPC1RAB9AFGFR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113329996-B | Compounds and methods for treating hedgehog pathway related disorders | 博远医药(苏州)有限公司 | 2023-03-10 | — | — | CN | disclosed |