SCHEMBL301820

CCc1c(-c2cn(-c3cc(C(=O)Nc4cc(C(F)(F)F)cc(NS(C)(=O)=O)c4OC)ccc3C)cn2)cnn1-c1ccccc1.CCc1c(-c2cn(-c3cc(C(=O)Nc4cc(C5(C)CC5)cc(NS(C)(=O)=O)c4OC)ccc3C)cn2)cnn1-c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	BRAF	P15056	19/20	0.41

▸	LYN	P07948	1/20	0.35

▸	MAPK9	P45984	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4031621	0.95	MAPK14 (0.38)	BRAFLYNMAPK9
SCHEMBL4034585	0.94	BRAF (0.43)	BRAF
SCHEMBL4035041	0.89	BRAF (0.45)	BRAF
SCHEMBL13887716	0.86	MAPK14 (0.35)	—
SCHEMBL13848991	0.85	MAPK14 (0.37)	—
SCHEMBL302476	0.85	MAPK14 (0.39)	BRAF
SCHEMBL13848623	0.85	MAPK14 (0.37)	—
SCHEMBL13887686	0.83	MAPK14 (0.38)	BRAFLYNMAPK9
SCHEMBL302056	0.82	TP53 (0.46)	BRAF
SCHEMBL4033513	0.81	BRAF (0.47)	BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
JP-4850824-B2	—	—	2012-01-11	—	—	JP	claimed
EP-1725544-A1	3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES	BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US)	2006-11-29	—	—	EP	claimed
WO-2005090333-A1	3-‘4-HETEROCYCLYL -1,2,3,-TRIAZOL-1-YL!-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES	BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US)	2005-09-29	—	—	WO	claimed