Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031621 | 0.89 | MAPK14 (0.38) | MAPK14RIPK2 | |
| SCHEMBL13848991 | 0.89 | MAPK14 (0.37) | MAPK14RIPK2MAPK11ALDH1A1MAPK1 | |
| SCHEMBL301820 | 0.85 | BRAF (0.41) | — | |
| SCHEMBL14297794 | 0.81 | RAB9A (0.35) | MAPK14RIPK2MAPK11 | |
| SCHEMBL13887716 | 0.80 | MAPK14 (0.35) | MAPK14RIPK2 | |
| SCHEMBL302476 | 0.79 | MAPK14 (0.39) | MAPK14 | |
| SCHEMBL13848693 | 0.79 | MAPK14 (0.40) | MAPK14RIPK2MAPK11 | |
| SCHEMBL4035041 | 0.79 | BRAF (0.45) | MAPK14 | |
| SCHEMBL4034585 | 0.78 | BRAF (0.43) | MAPK14 | |
| SCHEMBL304557 | 0.77 | MAPK14 (0.39) | MAPK14RIPK2MAPK11ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725544-B1 | 3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2009-05-27 | — | — | EP | disclosed |