Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 7/20 | 0.33 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
| ▸ | JAK1 | P23458 | 2/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123191 | 1.00 | PTK6 (0.35) | PTK6P2RX3TTKMAPKAPK5IRAK4 | |
| SCHEMBL30183513 | 0.93 | PTK6 (0.36) | PTK6TTKMAPKAPK5IDO1 | |
| SCHEMBL22123926 | 0.90 | CDK2 (0.32) | PTK6TTKCDK2CDK1 | |
| SCHEMBL22122966 | 0.90 | P2RX3 (0.36) | PTK6P2RX3TTKMAPKAPK5IRAK4 | |
| SCHEMBL24112476 | 0.90 | PTK6 (0.35) | PTK6P2RX3TTKMAPKAPK5CDK2 | |
| SCHEMBL22122968 | 0.89 | MAPKAPK5 (0.35) | PTK6P2RX3TTKMAPKAPK5CDK2 | |
| SCHEMBL30349936 | 0.89 | P2RX3 (0.35) | PTK6P2RX3TTKMAPKAPK5CDK2 | |
| SCHEMBL22122891 | 0.89 | TTK (0.35) | PTK6P2RX3TTKMAPKAPK5CDK2 | |
| SCHEMBL22124843 | 0.89 | P2RX3 (0.35) | PTK6P2RX3TTKMAPKAPK5CDK2 | |
| SCHEMBL25445314 | 0.88 | MAPKAPK5 (0.35) | PTK6P2RX3TTKMAPKAPK5CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898631-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |