Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 9/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30184362 | 0.85 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4331173 | 0.85 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8387420 | 0.83 | MEN1 (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL19605409 | 0.83 | HDAC8 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6174966 | 0.81 | SMN1; SMN2 (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8803613 | 0.80 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL201086 | 0.80 | PARP1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23957836 | 0.79 | KAT6A (0.61) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL30184164 | 0.79 | HPGD (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13702279 | 0.79 | SMN1; SMN2 (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116870016-B | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117412981-A | Phosphine oxide derivative and preparation method and application thereof | 希格生科（深圳）有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116870016-A | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115785154-A | Heteroaromatic ring compounds and medical use thereof | 希格生科（深圳）有限公司 | 2023-03-14 | — | — | CN | disclosed |