Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB4 | Q16877 | 4/20 | 0.61 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.61 |
| ▸ | SLC16A3 | O15427 | 8/20 | 0.56 |
| ▸ | CMA1 | P23946 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22134797 | 1.00 | PFKFB4 (0.61) | PFKFB4PFKFB3SLC16A3CMA1NPSR1 | |
| SCHEMBL22116481 | 0.86 | SLC16A3 (0.59) | PFKFB4PFKFB3SLC16A3CMA1 | |
| SCHEMBL22116587 | 0.80 | SLC16A3 (0.59) | SLC16A3 | |
| SCHEMBL30187910 | 0.80 | SLC16A3 (0.59) | SLC16A3 | |
| SCHEMBL5621758 | 0.80 | PFKFB3 (0.80) | PFKFB4PFKFB3CMA1NPSR1L3MBTL1 | |
| SCHEMBL3552003 | 0.80 | PFKFB4 (0.61) | PFKFB4PFKFB3SLC16A3CMA1NPSR1 | |
| SCHEMBL22116483 | 0.79 | SLC16A3 (0.51) | PFKFB4PFKFB3SLC16A3CMA1 | |
| SCHEMBL5621524 | 0.79 | PFKFB3 (0.70) | PFKFB4PFKFB3CMA1NPSR1L3MBTL1 | |
| SCHEMBL2912893 | 0.77 | CMA1 (0.82) | PFKFB4PFKFB3CMA1NPSR1L3MBTL1 | |
| SCHEMBL788108 | 0.76 | PFKFB4 (1.00) | PFKFB4PFKFB3CMA1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12351570-B2 | Disubstituted alkyne derivatives | MERCK PATENT GMBH (DE) | 2025-07-08 | — | — | US | claimed |
| US-12351570-B2 | Disubstituted alkyne derivatives | MERCK PATENT GMBH (DE) | 2025-07-08 | — | — | US | disclosed |
| US-20230052586-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12351570-B2 | Disubstituted alkyne derivatives | BRCA1, MYC, PCNA | PFKFB4 3772/4885PFKFB3 3714/4885SLC16A3 3198/4885 |
| US-20230052586-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | BRCA1, MYC, PCNA | PFKFB4 3772/4885PFKFB3 3714/4885SLC16A3 3198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.