⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609019 | 0.77 | KCNA5 (0.37) | — | |
| SCHEMBL13066097 | 0.77 | KCNA5 (0.37) | — | |
| SCHEMBL21954031 | 0.77 | HRH3 (0.38) | — | |
| SCHEMBL57306 | 0.77 | — | — | |
| SCHEMBL8648295 | 0.77 | — | — | |
| SCHEMBL24590305 | 0.74 | SMN1; SMN2 (0.40) | — | |
| Hydrochloric Acid SCHEMBL2139284 | 0.74 | PRKCG (0.40) | — | |
| SCHEMBL5962431 | 0.74 | SMN1; SMN2 (0.40) | — | |
| SCHEMBL14261286 | 0.74 | SMN1; SMN2 (0.40) | — | |
| SCHEMBL18085476 | 0.74 | SMN1; SMN2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729089-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2014-05-20 | — | — | US | claimed |
| US-8232279-B2 | Pyrazolopyrimidine derivatives having biological activity on serotonin receptor 5-HT2c | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-07-31 | — | — | US | claimed |
| US-20100298563-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES HAVING BIOLOGICAL ACTIVITY ON SEROTONIN RECEPTOR 5-HT2c | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-11-25 | — | — | US | claimed |
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-31 | — | — | US | claimed |
| US-8889691-B2 | Indole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2014-11-18 | — | — | US | disclosed |
| US-8729089-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20140024618-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2014-01-23 | — | — | US | disclosed |
| US-8569307-B2 | Indole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2013-10-29 | — | — | US | disclosed |
| EP-2178869-B1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD (KR) | 2013-06-12 | — | — | EP | disclosed |
| US-20120252798-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG CHEM, LTD. (KR) | 2012-10-04 | — | — | US | disclosed |
| US-8232279-B2 | Pyrazolopyrimidine derivatives having biological activity on serotonin receptor 5-HT2c | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-07-31 | — | — | US | disclosed |
| US-8222414-B2 | Indole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2012-07-17 | — | — | US | disclosed |
| EP-2049108-A1 | TREATMENT OF ENDOCRINE DYSFUNCTION USING IRON CHELATORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| EP-2026800-A1 | COMBINATION COMPRISING AN IRON CHELATOR AND AN ANTI-NEOPLASTIC AGENT AND USE THEREOF | Novartis AG (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2008142094-A1 | TRIAZOL COMPOUNDS FOR TREATING BIOFILM FORMATION | NOVARTIS AG (CH) | 2008-11-27 | — | — | WO | disclosed |
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-31 | — | — | US | disclosed |
| WO-2008015021-A1 | TREATMENT OF ENDOCRINE DYSFUNCTION USING IRON CHELATORS | NOVARTIS AG (CH) | 2008-02-07 | — | — | WO | disclosed |
| WO-2007128820-A1 | COMBINATION COMPRISING AN IRON CHELATOR AND AN ANTI-NEOPLASTIC AGENT AND USE THEREOF | NOVARTIS AG (CH) | 2007-11-15 | — | — | WO | disclosed |
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |