Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.53 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.50 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160048 | 1.00 | KMO (0.53) | KMODHODHL3MBTL1CES2CES1 | |
| SCHEMBL3210250 | 0.94 | KMO (0.60) | KMODHODHL3MBTL1RXRARXRB | |
| SCHEMBL121809 | 0.89 | KMO (0.68) | KMOCES2CES1RXRARXRB | |
| SCHEMBL122522 | 0.89 | DHODH (0.59) | KMODHODHHCAR1AXL | |
| SCHEMBL410738 | 0.87 | KMO (0.66) | KMODHODHRXRARXRBDCLRE1B | |
| SCHEMBL29784144 | 0.87 | KMO (0.66) | KMODHODHRXRARXRBDCLRE1B | |
| SCHEMBL3211056 | 0.87 | DHODH (0.62) | KMODHODHHCAR1AXL | |
| SCHEMBL14783757 | 0.86 | DHODH (0.57) | KMODHODHRXRARXRBNR4A1 | |
| SCHEMBL2557078 | 0.86 | KMO (0.51) | KMODHODHRXRARXRBHCAR1 | |
| SCHEMBL2554588 | 0.84 | TRIM24 (0.65) | KMODHODHRXRARXRBHCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |