Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29674595 | 0.78 | KDM4E (0.44) | POLBHSD17B10GAAMAPTKDM4E | |
| SCHEMBL2490420 | 0.78 | KDM4E (0.44) | POLBHSD17B10GAAMAPTKDM4E | |
| SCHEMBL2490424 | 0.78 | KDM4E (0.44) | POLBHSD17B10GAAMAPTKDM4E | |
| SCHEMBL10482650 | 0.67 | MAOB (0.64) | POLBMAPTL3MBTL1MIFALDH1A1 | |
| SCHEMBL14821850 | 0.67 | MAOB (0.64) | POLBMAPTL3MBTL1MIFALDH1A1 | |
| SCHEMBL333300 | 0.63 | MAPT (0.42) | POLBHSD17B10GAAMAPTKDM4E | |
| SCHEMBL3129135 | 0.63 | HSD17B10 (0.39) | POLBHSD17B10GAAMAPTKDM4E | |
| SCHEMBL12965293 | 0.62 | PARP1 (0.46) | GAAMAPTMIFCYP19A1 | |
| SCHEMBL12819448 | 0.62 | PARP1 (0.46) | GAAMAPTMIFCYP19A1 | |
| SCHEMBL15698076 | 0.61 | MIF (0.42) | MAPTHSP90AA1MIFALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |