Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | TNF | P01375 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.49 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000735 | 1.00 | MDM4 (0.55) | MDM4TP53TNFCASP3MDM2 | |
| SCHEMBL29401864 | 1.00 | MDM4 (0.55) | MDM4TP53TNFCASP3MDM2 | |
| SCHEMBL19899314 | 1.00 | MDM4 (0.55) | MDM4TP53TNFCASP3MDM2 | |
| SCHEMBL31165326 | 1.00 | MDM4 (0.55) | MDM4TP53TNFCASP3MDM2 | |
| SCHEMBL13611972 | 1.00 | MDM4 (0.55) | MDM4TP53TNFCASP3MDM2 | |
| SCHEMBL31037709 | 0.92 | MDM4 (0.49) | MDM4TP53TNFCASP3MDM2 | |
| SCHEMBL29818551 | 0.90 | MDM4 (0.54) | MDM4TP53CASP3MDM2SLC17A5 | |
| SCHEMBL29129111 | 0.88 | MDM4 (0.54) | MDM4TP53TNFCASP3MDM2 | |
| SCHEMBL29129108 | 0.88 | MDM4 (0.54) | MDM4TP53TNFCASP3MDM2 | |
| SCHEMBL29613460 | 0.88 | MDM4 (0.54) | MDM4TP53TNFCASP3MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230089867-A1 | CYCLIC PENTAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDER | NOVARTIS AG (CH) | 2023-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230089867-A1 | CYCLIC PENTAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDER | PCSK9, PCSK7, PCSK6 | MDM4 3803/4885TP53 1711/4885TNF 1980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.