Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301930 | 0.86 | CA1 (0.36) | CNR1MAPTTP53UTS2RKMT2A | |
| SCHEMBL3554952 | 0.85 | KDM4E (0.43) | CNR1MAPTTP53KMT2A | |
| SCHEMBL3932204 | 0.84 | CNR1 (0.37) | CNR1MAPTTP53UTS2RCACNA1H | |
| SCHEMBL3935356 | 0.82 | MAPT (0.39) | CNR1MAPTTP53UTS2RCACNA1H | |
| SCHEMBL3557589 | 0.82 | CNR1 (0.38) | CNR1MAPTTP53UTS2RKMT2A | |
| SCHEMBL301931 | 0.82 | CACNA1H (0.40) | CNR1MAPTTP53CACNA1HCYP2D6 | |
| SCHEMBL3556422 | 0.79 | KDM4E (0.40) | CNR1MAPTTP53UTS2RKMT2A | |
| SCHEMBL301836 | 0.75 | KDM4E (0.45) | CNR1MAPTTP53UTS2RKMT2A | |
| SCHEMBL3556286 | 0.75 | KDM4E (0.45) | CNR1MAPTTP53UTS2RKMT2A | |
| SCHEMBL3941457 | 0.74 | CNR1 (0.39) | CNR1MAPTTP53UTS2RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4851328-B2 | — | — | 2012-01-11 | — | — | JP | claimed |
| JP-2007506692-A | — | — | 2007-03-22 | — | — | JP | claimed |
| EP-1670470-A1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2006-06-21 | — | — | EP | claimed |
| WO-2005030209-A1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-04-07 | — | — | WO | claimed |