Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3557589 | 0.92 | CNR1 (0.38) | MAPTTP53CNR1KDM4EUTS2R | |
| SCHEMBL3932204 | 0.91 | CNR1 (0.37) | MAPTTP53CNR1KDM4EUTS2R | |
| SCHEMBL3936618 | 0.86 | CNR1 (0.40) | MAPTTP53CNR1KDM4EUTS2R | |
| SCHEMBL3562457 | 0.85 | HTR2A (0.53) | MAPTTP53CNR1UTS2RDRD2 | |
| SCHEMBL3554924 | 0.83 | L3MBTL1 (0.51) | MAPTTP53CNR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3565446 | 0.83 | HTR2A (0.53) | MAPTTP53UTS2RDRD2HTR2A | |
| SCHEMBL301931 | 0.83 | CACNA1H (0.40) | MAPTTP53CNR1DRD2CACNA1H | |
| SCHEMBL3562364 | 0.82 | L3MBTL1 (0.43) | TP53CNR1SMN1; SMN2L3MBTL1NAMPT | |
| SCHEMBL3552561 | 0.82 | KMT2A (0.42) | MAPTTP53UTS2RDRD2HTR2A | |
| SCHEMBL301932 | 0.82 | CNR1 (0.37) | MAPTTP53CNR1UTS2RDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670470-B1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-04-08 | — | — | EP | claimed |