Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 2/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 4/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 3/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22124549 | 0.94 | PTK6 (0.34) | PTK6MAPKAPK5TTKCDK2CDK1 | |
| SCHEMBL22123785 | 0.94 | MAPKAPK5 (0.35) | PTK6MAPKAPK5TGFBR1ACVRL1TTK | |
| SCHEMBL22123290 | 0.90 | MAPKAPK5 (0.34) | PTK6MAPKAPK5TTKCDK2CDK1 | |
| SCHEMBL30171532 | 0.90 | MAPKAPK5 (0.34) | PTK6MAPKAPK5TTKCDK2CDK1 | |
| SCHEMBL22124695 | 0.89 | CDK2 (0.35) | PTK6CDK2CDK1 | |
| SCHEMBL30171644 | 0.89 | CDK2 (0.35) | PTK6CDK2CDK1 | |
| Iodide SCHEMBL25169289 | 0.89 | PTK6 (0.35) | PTK6 | |
| SCHEMBL22124583 | 0.88 | MAPKAPK5 (0.33) | PTK6MAPKAPK5TTKCDK2CDK1 | |
| SCHEMBL22122823 | 0.88 | MAPKAPK5 (0.33) | PTK6MAPKAPK5TTKCDK2CDK1 | |
| SCHEMBL30171576 | 0.88 | MAPKAPK5 (0.33) | PTK6MAPKAPK5TTKCDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |
| EP-3898629-B1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |