Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 1.00 |
| ▸ | EGFR | P00533 | 2/20 | 1.00 |
| ▸ | INSR | P06213 | 7/20 | 0.86 |
| ▸ | IGF1R | P08069 | 7/20 | 0.86 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.78 |
| ▸ | AURKA | O14965 | 1/20 | 0.78 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.78 |
| ▸ | JAK2 | O60674 | 1/20 | 0.78 |
| ▸ | STK10 | O94804 | 1/20 | 0.78 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.78 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.78 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.78 |
| ▸ | ABL1 | P00519 | 1/20 | 0.78 |
| ▸ | CD74 | P04233 | 1/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.78 |
| ▸ | LCK | P06239 | 1/20 | 0.78 |
| ▸ | FYN | P06241 | 1/20 | 0.78 |
| ▸ | FES | P07332 | 1/20 | 0.78 |
| ▸ | CSF1R | P07333 | 1/20 | 0.78 |
| ▸ | YES1 | P07947 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iruplinalkib SCHEMBL30297159 | 1.00 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| Iruplinalkib SCHEMBL17411099 | 1.00 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17410973 | 0.95 | ALK (0.90) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL27270881 | 0.93 | ALK (0.87) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL11916443 | 0.93 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17411098 | 0.92 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17410976 | 0.92 | ALK (0.86) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17410982 | 0.92 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17410913 | 0.92 | ALK (0.84) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17411101 | 0.92 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12606578-B2 | Crystal form of spirocyclic amine aryl phosphorus oxide compound and preparation method therefor | QILU PHARMACEUTICAL CO., LTD. (CN) | 2026-04-21 | — | — | US | disclosed |
| US-20250282804-A1 | CRYSTAL FORM OF SPIROCYCLIC AMINE ARYL PHOSPHORUS OXIDE COMPOUND AND PREPARATION METHOD THEREFOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2025-09-11 | — | — | US | disclosed |
| WO-2023280090-A1 | PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 齐鲁制药有限公司 | 2023-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250282804-A1 | CRYSTAL FORM OF SPIROCYCLIC AMINE ARYL PHOSPHORUS OXIDE COMPOUND AND PREPARATION METHOD THEREFOR | P2RY11, PKD1, AGPS | ALK 394/4885EGFR 3509/4885INSR 1475/4885 |
| US-12606578-B2 | Crystal form of spirocyclic amine aryl phosphorus oxide compound and preparation method therefor | PAK4, PDPK1, PAK5 | ALK 812/4885EGFR 1065/4885INSR 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.