Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 1.00 |
| ▸ | EGFR | P00533 | 2/20 | 1.00 |
| ▸ | INSR | P06213 | 7/20 | 0.86 |
| ▸ | IGF1R | P08069 | 7/20 | 0.86 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.78 |
| ▸ | AURKA | O14965 | 1/20 | 0.78 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.78 |
| ▸ | JAK2 | O60674 | 1/20 | 0.78 |
| ▸ | STK10 | O94804 | 1/20 | 0.78 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.78 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.78 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.78 |
| ▸ | ABL1 | P00519 | 1/20 | 0.78 |
| ▸ | CD74 | P04233 | 1/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.78 |
| ▸ | LCK | P06239 | 1/20 | 0.78 |
| ▸ | FYN | P06241 | 1/20 | 0.78 |
| ▸ | FES | P07332 | 1/20 | 0.78 |
| ▸ | CSF1R | P07333 | 1/20 | 0.78 |
| ▸ | YES1 | P07947 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iruplinalkib SCHEMBL30195062 | 1.00 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| Iruplinalkib SCHEMBL17411099 | 1.00 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17410973 | 0.95 | ALK (0.90) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL27270881 | 0.93 | ALK (0.87) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL11916443 | 0.93 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17411098 | 0.92 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17410976 | 0.92 | ALK (0.86) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17410982 | 0.92 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17410913 | 0.92 | ALK (0.84) | ALKEGFRINSRIGF1RCHEK1 | |
| SCHEMBL17411101 | 0.92 | ALK (1.00) | ALKEGFRINSRIGF1RCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025238172-A1 | COMBINATIONS OF BRAF AND ALK/TRK INHIBITORS FOR COLORECTAL CANCER | GENOME RESEARCH LIMITED (GB) | 2025-11-20 | — | — | WO | disclosed |
| WO-2025103408-A1 | METHOD FOR TREATING ALK-POSITIVE OR ROS1-POSITIVE NON-SMALL CELL LUNG CANCER | 深圳市塔吉瑞生物医药有限公司 | 2025-05-22 | — | — | WO | disclosed |
| CN-222876583-U | Storage device is used in processing of following Lu Aoke impurity | 思科(深圳)药物研发有限公司 | 2025-05-16 | — | — | CN | disclosed |
| CN-119700981-A | Application of ALK/LTK inhibitor in preparation of products for treating and/or preventing chronic lymphocytic leukemia | 中南大学湘雅二医院 | 2025-03-28 | — | — | CN | disclosed |
| CN-115521309-A | Iruaoke impurity and preparation method thereof | 思科(深圳)药物研发有限公司 | 2022-12-27 | — | — | CN | disclosed |