Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | DTYMK | P23919 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | PPOX | P50336 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23581862 | 1.00 | AKR1B1 (0.45) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL9671806 | 0.86 | TSHR (0.44) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL24635525 | 0.84 | MAPK1 (0.46) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL30792124 | 0.83 | AKR1B1 (0.44) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL29190134 | 0.83 | AKR1B1 (0.44) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL22070445 | 0.81 | DTYMK (0.50) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4332289 | 0.79 | TSHR (0.58) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19280702 | 0.78 | TSHR (0.62) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL9748208 | 0.78 | TDP1 (0.46) | LMNAMAPTTSHRTDP1TTR | |
| SCHEMBL3758271 | 0.76 | TSHR (0.44) | AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113365994-B | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社 | 2024-08-09 | — | — | CN | disclosed |
| CN-115590854-B | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社 | 2024-06-07 | — | — | CN | disclosed |
| CN-115626919-A | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社 | 2023-01-20 | — | — | CN | disclosed |
| CN-115590854-A | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社（JP） | 2023-01-13 | — | — | CN | disclosed |