Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30196019 | 0.84 | ALDH1A1 (0.36) | TSHRSMN1; SMN2LMNAPOLBCYP1A2 | |
| SCHEMBL17212822 | 0.83 | TSHR (0.49) | TSHRSMN1; SMN2USP2RECQLPKM | |
| SCHEMBL15818630 | 0.81 | TSHR (0.44) | TSHRSMN1; SMN2USP2RECQLPKM | |
| SCHEMBL15818627 | 0.81 | TSHR (0.44) | TSHRSMN1; SMN2USP2RECQLPKM | |
| SCHEMBL15818631 | 0.81 | TSHR (0.44) | TSHRSMN1; SMN2USP2RECQLPKM | |
| SCHEMBL18133571 | 0.79 | TSHR (0.47) | TSHRSMN1; SMN2USP2RECQLPKM | |
| SCHEMBL17894913 | 0.78 | TSHR (0.53) | TSHRSMN1; SMN2USP2RECQLPKM | |
| SCHEMBL12206737 | 0.76 | TSHR (0.55) | TSHRSMN1; SMN2USP2RECQLPKM | |
| SCHEMBL15831114 | 0.76 | TSHR (0.56) | TSHRSMN1; SMN2USP2RECQLLMNA | |
| SCHEMBL697035 | 0.74 | TSHR (0.53) | TSHRSMN1; SMN2USP2RECQLPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584754-B2 | Derivatives of thailanstatin A, methods of treatment and methods of synthesis thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2023-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584754-B2 | Derivatives of thailanstatin A, methods of treatment and methods of synthesis thereof | NAMPT, FNTA, GNPAT | TSHR 2797/4885SMN1; SMN2 2181/4885USP2 4706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.