Known targets — ChEMBL curated mechanism
CSF1RFLT1FLT3FLT4KDRKITPDGFRAPDGFRBRET
The experimentally established mechanism targets of Sunitinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 16/20 | 0.92 |
| ▸ | PDGFRB known ✓ | P09619 | 7/20 | 0.92 |
| ▸ | CSF1R known ✓ | P07333 | 3/20 | 0.92 |
| ▸ | FLT3 known ✓ | P36888 | 3/20 | 0.92 |
| ▸ | RET known ✓ | P07949 | 2/20 | 0.92 |
| ▸ | FLT4 known ✓ | P35916 | 2/20 | 0.92 |
| ▸ | KIT known ✓ | P10721 | 2/20 | 0.92 |
| ▸ | PDGFRA known ✓ | P16234 | 1/20 | 0.92 |
| ▸ | FLT1 known ✓ | P17948 | 1/20 | 0.92 |
| ▸ | PRKAA1 | Q13131 | 13/20 | 0.92 |
| ▸ | PRKAA2 | P54646 | 12/20 | 0.92 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.92 |
| ▸ | EGFR | P00533 | 3/20 | 0.92 |
| ▸ | PLK4 | O00444 | 2/20 | 0.92 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.92 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.92 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.92 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.92 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.92 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sunitinib SCHEMBL28307868 | 1.00 | KDR (0.92) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL18648 | 1.00 | KDR (0.92) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL25343935 | 0.96 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL8081 | 0.96 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL20805212 | 0.96 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL25343938 | 0.96 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL8082 | 0.96 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL30314241 | 0.96 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL15265356 | 0.95 | KDR (0.95) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL1779742 | 0.95 | KDR (0.95) | KDRPRKAA1PRKAA2PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219492-B1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORP (US) | 2024-11-27 | — | — | EP | claimed |
| EP-3515904-B1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2024-01-17 | — | — | EP | claimed |
| EP-3674302-B1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | INCYTE HOLDINGS CORP (US) | 2023-03-01 | — | — | EP | claimed |