Known targets — ChEMBL curated mechanism
MAP3K10MAP3K11MAP3K12MAP3K13MAP3K9
The experimentally established mechanism targets of Cep-1347. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 known ✓ | Q16584 | 14/20 | 1.00 |
| ▸ | MAP3K9 known ✓ | P80192 | 12/20 | 1.00 |
| ▸ | MAP3K10 known ✓ | Q02779 | 8/20 | 1.00 |
| ▸ | KDR | P35968 | 4/20 | 1.00 |
| ▸ | FLT1 | P17948 | 1/20 | 1.00 |
| ▸ | FLT4 | P35916 | 1/20 | 1.00 |
| ▸ | DLK1 | P80370 | 1/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.93 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.74 |
| ▸ | PRKCG | P05129 | 3/20 | 0.74 |
| ▸ | PRKCB | P05771 | 3/20 | 0.74 |
| ▸ | PRKCA | P17252 | 3/20 | 0.74 |
| ▸ | PRKCH | P24723 | 3/20 | 0.74 |
| ▸ | PRKCI | P41743 | 3/20 | 0.74 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.74 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.74 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.74 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.74 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.74 |
| ▸ | MYLK | Q15746 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cep-1347 SCHEMBL29381680 | 1.00 | MAP3K11 (1.00) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| Cep-1347 SCHEMBL8263437 | 1.00 | MAP3K11 (1.00) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| Cep-1347 SCHEMBL12047710 | 1.00 | MAP3K11 (1.00) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| SCHEMBL13140134 | 0.97 | MAP3K11 (0.93) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| SCHEMBL13142263 | 0.97 | MAP3K11 (0.93) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| SCHEMBL12445000 | 0.95 | MAP3K11 (0.90) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| SCHEMBL5964631 | 0.93 | MAP3K11 (0.86) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| SCHEMBL29366906 | 0.91 | MAP3K11 (1.00) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| SCHEMBL15289975 | 0.91 | MAP3K11 (1.00) | MAP3K11MAP3K9MAP3K10KDRFLT1 | |
| SCHEMBL13234118 | 0.90 | MAP3K11 (0.81) | MAP3K11MAP3K9MAP3K10KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4662319-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | Integrate Bioscience LLC (US) | 2025-12-17 | — | — | EP | disclosed |
| US-20250290152-A1 | GENETIC TRIO OF BRAF AND TERT MUTATIONS AND RS2853669TT IN PAPILLARY THYROID CANCER AGGRESSIVENESS | THE JOHNS HOPKINS UNIVERSITY | 2025-09-18 | — | — | US | disclosed |
| US-20250262268-A1 | Methods and Compositions for Inhibiting Viral Infection | NEW YORK UNIVERSITY | 2025-08-21 | — | — | US | disclosed |
| US-20240366544-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | UNIV JOHNS HOPKINS (US) | 2024-11-07 | — | — | US | disclosed |
| WO-2024171957-A1 | TRANSPLANTATION OF PITUITARY HORMONE-PRODUCING CELLS | 国立大学法人東海国立大学機構 | 2024-08-22 | — | — | WO | disclosed |
| WO-2024168301-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | FUNCTION ONCOLOGY, INC. (US) | 2024-08-15 | — | — | WO | disclosed |
| US-11911356-B2 | Regulation of mutant TERT by BRAF V600E/map kinase pathway through FOS/GABP in human cancer | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-02-27 | — | — | US | disclosed |
| WO-2023054395-A1 | CELL AGGREGATE INCLUDING PITUITARY HORMONE-PRODUCING CELLS AND METHOD FOR PRODUCING SAME | 住友ファーマ株式会社 | 2023-04-06 | — | — | WO | disclosed |
| WO-2023054396-A1 | METHOD FOR PRODUCING CELL MASS INCLUDING PITUITARY TISSUE AND CELL MASS | 住友化学株式会社 | 2023-04-06 | — | — | WO | disclosed |
| WO-2023277135-A1 | METHOD FOR PRODUCING CELLS CONSTITUTING NASAL EPITHELIUM, AND CELL POPULATION INCLUDING CELLS CONSTITUTING NASAL EPITHELIUM OR PROGENITOR CELLS THEREOF | 住友化学株式会社 | 2023-01-05 | — | — | WO | disclosed |