Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | IDH1 | O75874 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833728 | 1.00 | LMNA (0.53) | LMNAMEN1KMT2AHTTNPSR1 | |
| SCHEMBL23846545 | 0.91 | HDAC1 (0.56) | LMNAMEN1KMT2AHTTGAA | |
| SCHEMBL23846438 | 0.90 | KMT2A (0.62) | LMNAMEN1KMT2AHTTGAA | |
| SCHEMBL23846635 | 0.89 | LMNA (0.50) | LMNAMEN1KMT2AHTTGAA | |
| SCHEMBL30199534 | 0.89 | LMNA (0.52) | LMNAMEN1KMT2AHTTNPSR1 | |
| SCHEMBL23833764 | 0.89 | LMNA (0.52) | LMNAMEN1KMT2AHTTNPSR1 | |
| SCHEMBL25758942 | 0.83 | LMNA (0.59) | LMNAMEN1KMT2AHTTNPSR1 | |
| SCHEMBL23846650 | 0.81 | LMNA (0.54) | LMNAMEN1KMT2AHTTNPSR1 | |
| SCHEMBL23846582 | 0.80 | LMNA (0.56) | LMNAMEN1KMT2AHTTNPSR1 | |
| SCHEMBL23846316 | 0.80 | LMNA (0.58) | LMNAMEN1KMT2AHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121029-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | Amathus Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |