Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20815887 | 1.00 | KDM1A (0.39) | KDM1ABACE1OPRM1OPRL1PDK2 | |
| SCHEMBL16972026 | 0.78 | KDM1A (0.37) | KDM1ABACE1OPRM1OPRL1PDK2 | |
| SCHEMBL8271540 | 0.75 | KDM1A (0.46) | KDM1ABACE1OPRM1GAAMEN1 | |
| SCHEMBL25231375 | 0.74 | TNKS (0.40) | KDM1ABACE1OPRM1OPRL1PDE7A | |
| SCHEMBL29384370 | 0.73 | PDK2 (0.42) | KDM1ABACE1OPRM1OPRL1PDK2 | |
| SCHEMBL29479467 | 0.73 | TNKS (0.44) | KDM1ABACE1OPRM1OPRL1PDK2 | |
| SCHEMBL27408376 | 0.73 | KDM1A (0.39) | KDM1ABACE1OPRM1OPRL1PDK2 | |
| SCHEMBL1012828 | 0.73 | TNKS (0.44) | KDM1ABACE1OPRM1OPRL1PDK2 | |
| SCHEMBL1031209 | 0.73 | PDK2 (0.42) | KDM1ABACE1OPRM1OPRL1PDK2 | |
| Hydrochloric Acid SCHEMBL2482151 | 0.71 | PDK2 (0.41) | KDM1ABACE1OPRM1OPRL1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946103-A | Preparation method of chiral quaternary carbon-containing 3, 3-difluoroindole compound | 云南民族大学 | 2024-04-30 | — | — | CN | claimed |
| US-12286429-B2 | 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives useful as a factor XIa inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2025-04-29 | — | — | US | disclosed |
| CN-117946103-A | Preparation method of chiral quaternary carbon-containing 3, 3-difluoroindole compound | 云南民族大学 | 2024-04-30 | — | — | CN | disclosed |
| US-20230064443-A1 | 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide Derivatives Useful As a Factor XIa Inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2023-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12286429-B2 | 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives useful as a factor XIa inhibitors | F11, F12, F13A1 | KDM1A 428/4885BACE1 1909/4885OPRM1 2452/4885 |
| US-20230064443-A1 | 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide Derivatives Useful As a Factor XIa Inhibitors | F11, F12, F13A1 | KDM1A 461/4885BACE1 1719/4885OPRM1 2133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.