Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Jnj-42165279. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH known ✓ | O00519 | 16/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Jnj-42165279 SCHEMBL2585102 | 1.00 | FAAH (1.00) | FAAHCYP2D6CA12CA1CA2 | |
| Jnj-42165279 SCHEMBL29392521 | 1.00 | FAAH (1.00) | FAAHCYP2D6CA12CA1CA2 | |
| Jnj-42165279 SCHEMBL31616215 | 0.99 | FAAH (0.98) | FAAHCYP2D6CA12CA1CA2 | |
| Jnj-42165279 SCHEMBL2588988 | 0.99 | FAAH (0.98) | FAAHCYP2D6CA12CA1CA2 | |
| SCHEMBL15673544 | 0.86 | FAAH (0.76) | FAAHCYP2D6MCHR1 | |
| SCHEMBL3590970 | 0.84 | FAAH (1.00) | FAAHCYP2D6MAPK1 | |
| SCHEMBL2593197 | 0.83 | FAAH (1.00) | FAAHCYP2D6 | |
| SCHEMBL3637158 | 0.83 | FAAH (0.76) | FAAHCYP2D6MAPK1 | |
| SCHEMBL3598626 | 0.81 | FAAH (1.00) | FAAHCYP2D6MAPK1 | |
| SCHEMBL1277125 | 0.81 | FAAH (0.68) | FAAHCYP2D6MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115616216-A | Use of an agent that inhibits or blocks the interaction between FAAH and NLRP3 | 华南理工大学 | 2023-01-17 | — | — | CN | claimed |
| WO-2025120480-A1 | METHODS FOR TREATING SUBJECTS WITH AUTISM SPECTRUM DISORDER | JANSSEN PHARMACEUTICA NV (BE) | 2025-06-12 | — | — | WO | disclosed |
| WO-2024225481-A1 | AGENT FOR IMPROVING THERAPEUTIC RESPONSIVENESS IN CANCER IMMUNOTHERAPY WITH PD-1 INHIBITOR OR PD-L1 INHIBITOR | 国立大学法人京都大学 | 2024-10-31 | — | — | WO | disclosed |
| WO-2024102802-A1 | ZELATRIAZIN FOR THE TREATMENT OF DEPRESSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-05-16 | — | — | WO | disclosed |
| CN-115616216-A | Use of an agent that inhibits or blocks the interaction between FAAH and NLRP3 | 华南理工大学 | 2023-01-17 | — | — | CN | disclosed |