SCHEMBL30201534

SCHEMBL30201534

COC(=O)c1ccc2ccn(-c3ccccc3)c2c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 2/20 0.56
KDM4E B2RXH2 3/20 0.50
HPGD P15428 3/20 0.50
ALDH1A1 P00352 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
POLB P06746 1/20 0.50
APOBEC3A P31941 1/20 0.50
HSD17B10 Q99714 1/20 0.50
APOBEC3G Q9HC16 1/20 0.50
NPC1 O15118 1/20 0.46
TSHR P16473 1/20 0.46
NR4A2 P43354 1/20 0.46
CYP3A4 P08684 2/20 0.46
LMNA P02545 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
TRPA1 O75762 1/20 0.43
MEN1 O00255 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4604283 1.00 FGFR1 (0.56) FGFR1KDM4EHPGDALDH1A1SMN1; SMN2
SCHEMBL3975054 0.89 FGFR1 (0.60) FGFR1KDM4EHPGDALDH1A1SMN1; SMN2
SCHEMBL25998835 0.87 CA12 (0.51) FGFR1KDM4EHPGDALDH1A1SMN1; SMN2
SCHEMBL346432 0.87 TDP1 (0.51) FGFR1KDM4EHPGDALDH1A1SMN1; SMN2
SCHEMBL18002655 0.86 KDM4E (0.54) KDM4EHPGDALDH1A1SMN1; SMN2POLB
SCHEMBL16720753 0.86 ALDH1A1 (0.48) FGFR1KDM4EHPGDALDH1A1SMN1; SMN2
SCHEMBL18002810 0.85 POLB (0.46) FGFR1KDM4EHPGDALDH1A1SMN1; SMN2
SCHEMBL3491657 0.84 ALDH1A1 (0.46) FGFR1KDM4EHPGDALDH1A1SMN1; SMN2
SCHEMBL24950460 0.83 FGFR1 (0.55) FGFR1KDM4EHSD17B10TSHRF2
SCHEMBL30201454 0.83 FGFR1 (0.55) FGFR1KDM4EHSD17B10TSHRF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023009330-A1 SEROTONIN 5-HT2B INHIBITORY COMPOUNDS ZOETIS SERVICES LLC (US) 2023-02-02 WO disclosed