Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.49 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.45 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.45 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.45 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.45 |
| ▸ | CACNA1E | Q15878 | 2/20 | 0.45 |
| ▸ | CACNA2D4 | Q7Z3S7 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25074065 | 1.00 | GPR119 (0.51) | GPR119PRMT5CACNB4CACNA1ACACNA1G | |
| SCHEMBL29223506 | 0.91 | PRMT5 (0.53) | GPR119PRMT5CACNB4CACNA1ACACNA1G | |
| SCHEMBL30830568 | 0.87 | PRMT5 (0.47) | GPR119PRMT5CACNB4CACNA1ACACNA1G | |
| SCHEMBL30831113 | 0.87 | GPR119 (0.48) | GPR119PRMT5CACNB4CACNA1ACACNA1G | |
| SCHEMBL24206930 | 0.86 | PRMT5 (0.52) | GPR119PRMT5PIK3CDHPGDSYAP1 | |
| SCHEMBL25188954 | 0.86 | DDB1 (0.43) | GPR119PRMT5CACNB4CACNA1ACACNA1G | |
| SCHEMBL10196271 | 0.84 | PRMT5 (0.52) | GPR119PRMT5CACNB4CACNA1ACACNA1G | |
| SCHEMBL25199235 | 0.84 | GPR119 (0.53) | GPR119PRMT5 | |
| SCHEMBL30888790 | 0.84 | GPR119 (0.53) | GPR119PRMT5 | |
| SCHEMBL31382255 | 0.84 | PRMT5 (0.53) | GPR119PRMT5YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367118-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | Nurix Therapeutics, Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023023255-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-02-23 | — | — | WO | disclosed |