Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25074367 | 1.00 | KMT2A (0.48) | KMT2AL3MBTL1AKR1C3KDM4EABL1 | |
| SCHEMBL29592865 | 0.86 | KDM4E (0.60) | KMT2AL3MBTL1AKR1C3KDM4EABL1 | |
| SCHEMBL24312784 | 0.86 | KDM4E (0.60) | KMT2AL3MBTL1AKR1C3KDM4EABL1 | |
| SCHEMBL13009560 | 0.85 | KDM4E (0.48) | KMT2AL3MBTL1KDM4EABL1LMNA | |
| SCHEMBL21427084 | 0.84 | KDM4E (0.48) | KMT2AL3MBTL1KDM4EABL1LMNA | |
| SCHEMBL21679479 | 0.83 | GPR119 (0.48) | KDM4EGPR119PANK3ALDH1A1 | |
| SCHEMBL374689 | 0.82 | USP30 (0.55) | KMT2AL3MBTL1KDM4EGPR119MEN1 | |
| SCHEMBL24670864 | 0.82 | PPARG (0.45) | KMT2AL3MBTL1AKR1C3GPR119PPARG | |
| SCHEMBL29990449 | 0.82 | PPARG (0.45) | KMT2AL3MBTL1AKR1C3GPR119PPARG | |
| SCHEMBL3025692 | 0.82 | CKS1B (0.60) | AKR1C3GPR119PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024222726-A1 | DEGRADATION AGENT FOR CYCLIN-DEPENDENT KINASE (CDK) 12/13, COMPOSITION AND USE THEREOF | 浙江大学 | 2024-10-31 | — | — | WO | disclosed |
| EP-4367118-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | Nurix Therapeutics, Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023023255-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-02-23 | — | — | WO | disclosed |