Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 5/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927164 | 1.00 | PTAFR (0.43) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23881507 | 0.91 | PTAFR (0.42) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL30089236 | 0.91 | PTAFR (0.42) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL30202034 | 0.90 | P2RX7 (0.38) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23927178 | 0.90 | P2RX7 (0.38) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23927163 | 0.89 | P2RX7 (0.42) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL30201992 | 0.89 | P2RX7 (0.42) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23927170 | 0.88 | P2RX7 (0.35) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL30201991 | 0.88 | P2RX7 (0.35) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23927148 | 0.85 | PTAFR (0.42) | PTAFRGABRA1GABRA5GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | claimed |
| CN-115667262-A | Benzodiazepine derivatives as GABAA γ 1PAM | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | claimed |
| EP-4139310-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | disclosed |
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |
| CN-115667262-A | Benzodiazepine derivatives as GABAA γ 1PAM | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |