Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 13/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927128 | 1.00 | CHRM1 (0.65) | CHRM1ALOX12SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL30201999 | 0.88 | CHRM1 (0.62) | CHRM1ALOX12SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23881593 | 0.88 | CHRM1 (0.62) | CHRM1ALOX12SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23927146 | 0.87 | CHRM1 (0.51) | CHRM1ALOX12SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23927112 | 0.86 | CHRM1 (0.60) | CHRM1ALOX12SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL30202003 | 0.86 | CHRM1 (0.60) | CHRM1ALOX12SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL30202032 | 0.85 | LMNA (0.65) | CHRM1LMNAGABRA1GABRA5GABRA3 | |
| SCHEMBL23927216 | 0.85 | LMNA (0.65) | CHRM1LMNAGABRA1GABRA5GABRA3 | |
| SCHEMBL11868671 | 0.83 | CHRM1 (0.61) | CHRM1ALOX12SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7330104 | 0.82 | CHRM1 (0.68) | CHRM1ALOX12SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4408848-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2024-08-07 | — | — | EP | disclosed |
| EP-4405043-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2024-07-31 | — | — | EP | disclosed |
| CN-118043326-A | Benzodiazepine derivatives as GABAA γ1 PAM | 豪夫迈·罗氏有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-118019742-A | Novel benzodiazepine derivatives as GABA Aγ1 PAM | 豪夫迈·罗氏有限公司 | 2024-05-10 | — | — | CN | disclosed |
| WO-2023052312-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2023-04-06 | — | — | WO | disclosed |
| WO-2023046817-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-30 | — | — | WO | disclosed |
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |