Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17205475 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL17447124 | 0.89 | MAP2K4 (0.54) | KDM4EALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL13208508 | 0.87 | KIF11 (0.53) | KDM4EALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL4404502 | 0.84 | MAP2K4 (0.46) | ALDH1A1MAP2K4KIF11MAPK1MAPKAPK3 | |
| SCHEMBL30205015 | 0.82 | MAP2K4 (0.57) | KDM4EALDH1A1MAP2K4HPGDKIF11 | |
| SCHEMBL2671448 | 0.82 | MAP2K4 (0.57) | KDM4EALDH1A1MAP2K4HPGDKIF11 | |
| SCHEMBL4400777 | 0.82 | MAP2K4 (0.44) | MAP2K4FLT3MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL24422909 | 0.81 | MAP2K4 (0.54) | KDM4EALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL16929779 | 0.80 | JAK2 (0.58) | KDM4EALDH1A1L3MBTL1MAP2K4RAB9A | |
| SCHEMBL1501529 | 0.80 | KDM4E (0.55) | KDM4EALDH1A1L3MBTL1MAP2K4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858877-A | C-linked inhibitors of ENL/AF9 YEATS | 桥梁药品有限公司 | 2024-04-09 | — | — | CN | disclosed |
| EP-4337662-A1 | C-LINKED INHIBITORS OF ENL/AF9 YEATS | Bridge Medicines (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240830-A1 | C-LINKED INHIBITORS OF ENL/AF9 YEATS | BRIDGE MEDICINES (US) | 2022-11-17 | — | — | WO | disclosed |