Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | WDR5 | P61964 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3211887 | 0.84 | IRAK4 (0.49) | AKR1C2AKR1C1IRAK4MEN1KMT2A | |
| SCHEMBL3035849 | 0.82 | MAPT (0.47) | AKR1C2AKR1C1IRAK4MEN1KMT2A | |
| SCHEMBL1724611 | 0.81 | AKR1C2 (0.67) | AKR1C2AKR1C1IRAK4MEN1KMT2A | |
| SCHEMBL1455710 | 0.80 | MAPT (0.62) | AKR1C2AKR1C1MEN1KMT2ARAB9A | |
| SCHEMBL1454722 | 0.78 | KMT2A (0.65) | AKR1C2AKR1C1MEN1KMT2ARAB9A | |
| SCHEMBL15358859 | 0.78 | AKR1C2 (0.59) | AKR1C2AKR1C1IRAK4MEN1KMT2A | |
| SCHEMBL13508178 | 0.78 | IRAK4 (0.45) | AKR1C2AKR1C1IRAK4MEN1KMT2A | |
| SCHEMBL27864010 | 0.78 | AKR1C2 (0.63) | AKR1C2AKR1C1IRAK4MEN1KMT2A | |
| SCHEMBL1275543 | 0.77 | IRAK4 (0.45) | AKR1C2AKR1C1IRAK4MEN1KMT2A | |
| SCHEMBL2554714 | 0.77 | AKR1C2 (0.54) | AKR1C2AKR1C1IRAK4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236828-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-08-07 | — | — | US | disclosed |
| US-8236828-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-08-07 | — | — | US | disclosed |
| US-8236828-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-08-07 | — | — | US | disclosed |
| EP-2212304-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-21 | — | — | EP | disclosed |
| EP-2212304-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-21 | — | — | EP | disclosed |
| CN-101827830-A | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG | 2010-09-08 | — | — | CN | disclosed |
| US-20100216850-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-26 | — | — | US | disclosed |
| US-20100216850-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-26 | — | — | US | disclosed |
| US-20100216850-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-26 | — | — | US | disclosed |
| EP-2212304-A1 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009049844-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009049844-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216850-A1 | INSECTICIDAL COMPOUNDS | CHRM1, ACHE, CHRM2 | AKR1C2 1009/4885AKR1C1 615/4885IRAK4 4377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.