Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 4/20 | 0.35 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24948369 | 0.89 | NAMPT (0.53) | NAMPTCYP3A4CYP2C9BCHEACHE | |
| SCHEMBL24947604 | 0.75 | NAMPT (0.67) | NAMPTCYP3A4CYP2C9BCHEACHE | |
| SCHEMBL21060370 | 0.74 | NAMPT (0.71) | NAMPTCYP3A4CYP2C9BCHEACHE | |
| SCHEMBL19317565 | 0.72 | NAMPT (0.82) | NAMPTCYP3A4CYP2C9BCHEACHE | |
| SCHEMBL19834837 | 0.66 | NAMPT (0.65) | NAMPTCYP3A4CYP2C9BCHEACHE | |
| Daporinad SCHEMBL82368 | 0.66 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9 | |
| Daporinad SCHEMBL156944 | 0.66 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9 | |
| SCHEMBL19834849 | 0.66 | NAMPT (0.80) | NAMPTCYP3A4CYP2C9BCHEACHE | |
| Daporinad SCHEMBL82367 | 0.66 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9 | |
| Daporinad SCHEMBL31181445 | 0.66 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377300-A1 | 6-SUBSTITUTED NAPHTHALENE-1,3-DISULFONIC ACID DERIVATIVES AS MODULATORS OF THE EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE (ENAMPT) FOR THE TREATMENT OF E.G. DIABETES | The University of Manchester (GB) | 2024-06-05 | — | — | EP | claimed |
| WO-2023007147-A1 | 6-SUBSTITUTED NAPHTHALENE-1,3-DISULFONIC ACID DERIVATIVES AS MODULATORS OF THE EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE (ENAMPT) FOR THE TREATMENT OF E.G. DIABETES | THE UNIVERSITY OF MANCHESTER (GB) | 2023-02-02 | — | — | WO | claimed |
| EP-4377300-A1 | 6-SUBSTITUTED NAPHTHALENE-1,3-DISULFONIC ACID DERIVATIVES AS MODULATORS OF THE EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE (ENAMPT) FOR THE TREATMENT OF E.G. DIABETES | The University of Manchester (GB) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023007147-A1 | 6-SUBSTITUTED NAPHTHALENE-1,3-DISULFONIC ACID DERIVATIVES AS MODULATORS OF THE EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE (ENAMPT) FOR THE TREATMENT OF E.G. DIABETES | THE UNIVERSITY OF MANCHESTER (GB) | 2023-02-02 | — | — | WO | disclosed |