Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 5/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 4/20 | 0.49 |
| ▸ | ROS1 | P08922 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.47 |
| ▸ | STAT6 | P42226 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173538 | 1.00 | EML4 (0.54) | EML4ALKMAPK8MAPK9MAPK10 | |
| SCHEMBL29173638 | 0.91 | PTK2 (0.46) | EML4ALKMAPK8MAPK9MAPK10 | |
| SCHEMBL30206096 | 0.91 | PTK2 (0.46) | EML4ALKMAPK8MAPK9MAPK10 | |
| SCHEMBL29173401 | 0.89 | EML4 (0.56) | EML4ALKMAPK8MAPK9MAPK10 | |
| SCHEMBL30206368 | 0.89 | EML4 (0.56) | EML4ALKMAPK8MAPK9MAPK10 | |
| SCHEMBL30206068 | 0.85 | EML4 (0.58) | EML4ALKMAPK8MAPK9MAPK10 | |
| SCHEMBL29173494 | 0.85 | EML4 (0.58) | EML4ALKMAPK8MAPK9MAPK10 | |
| SCHEMBL10126777 | 0.82 | EML4 (0.67) | EML4ALKMAPK8MAPK9MAPK10 | |
| SCHEMBL29173515 | 0.80 | PIM1 (0.48) | EML4ALKJAK3SYKSTAT6 | |
| SCHEMBL30206208 | 0.80 | PIM1 (0.48) | EML4ALKJAK3SYKSTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |