SCHEMBL30207889

SCHEMBL30207889

Cc1ncnc2c1ccn2[C@@H]1C[C@H](CI)[C@H]2OC(C)(C)O[C@H]21

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 0.38
WDR77 Q9BQA1 13/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19667495 1.00 PRMT5 (0.38) PRMT5WDR77
SCHEMBL19667281 0.89 PRMT5 (0.42) PRMT5WDR77
SCHEMBL30207873 0.89 PRMT5 (0.42) PRMT5WDR77
SCHEMBL10186264 0.89 PRMT5 (0.42) PRMT5WDR77
SCHEMBL17536694 0.88 NNMT (0.38) PRMT5WDR77
SCHEMBL19667148 0.83 PRMT5 (0.43) PRMT5WDR77
SCHEMBL19679322 0.83 PRMT5 (0.43) PRMT5WDR77
SCHEMBL30207970 0.83 PRMT5 (0.43) PRMT5WDR77
SCHEMBL10186266 0.82 RXFP1 (0.39) PRMT5WDR77
SCHEMBL30207950 0.81 PRMT5 (0.42) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109890797-B Substituted carbon nucleoside derivatives useful as anticancer agents 辉瑞公司 2023-02-28 CN disclosed