Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 6/20 | 0.42 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | USP1 | O94782 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31548661 | 0.75 | PDE2A (0.63) | PDE9APDE2A | |
| SCHEMBL20339535 | 0.75 | PDE2A (0.63) | PDE9APDE2A | |
| SCHEMBL23991845 | 0.70 | PDE2A (0.76) | PDE9APDE2A | |
| SCHEMBL12197739 | 0.67 | CHRNA7 (0.46) | PDE9AIDH1KMT2ACDK13CDK12 | |
| SCHEMBL30598725 | 0.66 | PDE9A (0.41) | PDE9APDE2AIDH1USP1 | |
| SCHEMBL28618180 | 0.65 | NOTUM (0.38) | PDE9AIDH1CDK13CDK12 | |
| SCHEMBL22092394 | 0.65 | NOTUM (0.38) | PDE9AIDH1KMT2ACDK13CDK12 | |
| SCHEMBL28618177 | 0.65 | NOTUM (0.38) | PDE9AIDH1CDK13CDK12 | |
| SCHEMBL24774146 | 0.65 | NOTUM (0.38) | PDE9AIDH1KMT2ADGKZCDK13 | |
| SCHEMBL21984790 | 0.64 | PDE9A (0.49) | PDE9ADGKZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110337437-B | Substituted pyrazolopyrimidinones as PDE2 inhibitors | 达特神经科学有限公司 | 2023-02-03 | — | — | CN | disclosed |