Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 9/20 | 0.41 |
| ▸ | PDE2A | O00408 | 4/20 | 0.37 |
| ▸ | USP1 | O94782 | 5/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30598717 | 0.78 | PDE9A (0.40) | PDE9APDE2A | |
| SCHEMBL31548661 | 0.67 | PDE2A (0.63) | PDE9APDE2A | |
| SCHEMBL20339535 | 0.67 | PDE2A (0.63) | PDE9APDE2A | |
| SCHEMBL30209342 | 0.66 | PDE9A (0.42) | PDE9APDE2AUSP1IDH1 | |
| SCHEMBL23991845 | 0.66 | PDE2A (0.76) | PDE9APDE2A | |
| SCHEMBL24774146 | 0.62 | NOTUM (0.38) | PDE9AIDH1 | |
| SCHEMBL12197739 | 0.62 | CHRNA7 (0.46) | PDE9AIDH1 | |
| SCHEMBL24214770 | 0.60 | CYP1A2 (0.31) | — | |
| SCHEMBL25935036 | 0.60 | NPSR1 (0.39) | IDH1 | |
| SCHEMBL22092394 | 0.59 | NOTUM (0.38) | PDE9AIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894413-B1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-11-15 | — | — | EP | disclosed |