Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11736164 | 1.00 | CLK1 (0.49) | CLK1DYRK1AIMPDH2GAAKDM4E | |
| SCHEMBL6794058 | 0.79 | CYP2A6 (0.50) | CLK1DYRK1AIMPDH2GAAKDM4E | |
| Hydrochloric Acid SCHEMBL11737866 | 0.78 | CYP2A6 (0.48) | CLK1DYRK1AIMPDH2GAAKDM4E | |
| SCHEMBL27040501 | 0.76 | IMPDH2 (0.43) | CLK1DYRK1AIMPDH2GAAKDM4E | |
| SCHEMBL11743241 | 0.76 | CLK1 (0.41) | CLK1DYRK1AIMPDH2GAAKDM4E | |
| SCHEMBL10921238 | 0.76 | IMPDH2 (0.72) | CLK1DYRK1AIMPDH2GAAKDM4E | |
| SCHEMBL27332884 | 0.76 | EP300 (0.53) | CLK1DYRK1AIMPDH2KDM4EPOLB | |
| SCHEMBL31586019 | 0.75 | MAP4K1 (0.41) | IMPDH2GAAMAP4K1CYP3A4 | |
| SCHEMBL672509 | 0.75 | CLK1 (0.54) | CLK1DYRK1AIMPDH2KDM4EPOLB | |
| SCHEMBL29569821 | 0.75 | CLK1 (0.54) | CLK1DYRK1AIMPDH2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566003-B2 | Isoquinolines as inhibitors of HPK1 | GENENTECH, INC. (US) | 2023-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11566003-B2 | Isoquinolines as inhibitors of HPK1 | HIPK1, HIPK2, IP6K1 | CLK1 29/4885DYRK1A 1204/4885IMPDH2 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.