Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.59 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.55 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.48 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31146810 | 1.00 | PARP10 (0.65) | PARP10CHEK2PARP2PARP4CA1 | |
| SCHEMBL3011807 | 0.95 | PARP10 (0.71) | PARP10CHEK2PARP2PARP4CA1 | |
| SCHEMBL13350009 | 0.92 | PARP10 (0.59) | PARP10CHEK2PARP2PARP4CA1 | |
| SCHEMBL8421294 | 0.90 | PARP10 (0.59) | PARP10CHEK2PARP2PARP4CA1 | |
| SCHEMBL3014872 | 0.87 | PARP10 (0.69) | PARP10PARP2PARP4CA1CA2 | |
| SCHEMBL2855827 | 0.86 | MAPT (0.58) | PARP10MAPTCHEK1RARBRAB9A | |
| SCHEMBL17963079 | 0.86 | PARP10 (0.64) | PARP10CHEK2PARP2PARP4CA1 | |
| SCHEMBL20574599 | 0.86 | MAPT (0.58) | PARP10MAPTCHEK1RARBRAB9A | |
| SCHEMBL3028004 | 0.86 | PARP10 (0.64) | PARP10CHEK2PARP2PARP4CA1 | |
| SCHEMBL15562010 | 0.85 | RARB (0.68) | CA1CA2MAPTRARBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204224-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS | VERNALIS R & D LIMITED (GB) | 2010-08-12 | — | — | US | disclosed |
| EP-1910374-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007007069-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204224-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS | SCN1B, SCN2B, SCN1A | PARP10 3946/4885CHEK2 4635/4885PARP2 4522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.